Towards pills that can mimick many of the benefits of exercise

Everyone knows that exercise improves health, and ongoing research continues to uncover increasingly detailed information on its benefits for metabolism, circulation, and improved functioning of organs such as the heart, brain, and liver. With this knowledge in hand, scientists may be better equipped to develop "exercise pills" that could mimic at least some of the beneficial effects of physical exercise on the body. But a review of current development efforts, publishing October 2 in Trends in Pharmacological Sciences, ponders whether such pills will achieve their potential therapeutic impact, at least in the near future. 

Several laboratories are developing exercise pills, which at this early stage are being tested in animals to primarily target skeletal muscle performance and improve strength and energy use--essentially producing stronger and faster muscles. But of course the benefits of exercise are far greater than its effects on only muscles.

"Clearly people derive many other rewarding experiences from exercise--such as increased cognitive function, bone strength, and improved cardiovascular function," says Laher. "It is unrealistic to expect that exercise pills will fully be able to substitute for physical exercise--at least not in the immediate future."


Figure from an earlier 2013 look at exercise polypill


Physiology online - Exercise is the Real Polypill (2013)

Trends in Pharmacological Sciences - Exercise Pills: At the Starting Line (2015)

Read more » at  Next Big Future

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